Balancing blood sugar can be hard, but nature helps. Some ingredients are powerful and proven to help control blood sugar. They can boost insulin, steady energy, and reduce sugar spikes. These natural wonders have been used for years and are backed by science. In this list, we share the top ten ingredients that work best. Discover what they are and how they can help you.

Written By: Glucose Guild Staff

Reviewed by Paul Fuller, NP

Supplement Name	Active Ingredients per Serving	Proprietary Blend	Other Ingredients
Blood Sugar Blaster	Vitamin C: 50 mg (84% DV), Zinc: 7.5 mg (68% DV), Chromium: 2 mcg (6% DV)	Turmeric, Cinnamon, Prickly Pear, Cassia, Goji Berry, Bitter Melon, Holy Basil, Olive Leaf	Gelatin Capsule, Rice Powder, Magnesium Stearate, Microcrystalline Cellulose, Silicon Dioxide
CelluCare	Vitamin C: 90 mg (100% DV), Vitamin D: 25 mcg (125% DV), Magnesium: 20 mg (5% DV), Chromium: 100 mcg (286% DV)	Turmeric, Cocoa, Berberine, Gymnema, Cinnamon, Clove, Eleuthero, Juniper, Pine, Bitter Melon, Holy Basil, Buchu, Barberry, Rhodiola, Brassica, Cuggul	Hypromellose, Microcrystalline Cellulose, Magnesium Stearate, Stearic Acid, Silicon Dioxide
Curalin	Calories: 3.7, Total Fat: 5.8 mg, Carbohydrate: 4 mg, Dietary Fibers: 199.3 mg, Sugars: 5 mg, Protein: 814 mg, Iron: 1.21 mg	Mormordica charantia, Syzygium Cumini, Swertia Chirayita, Trigonella Foenum Graecum, Gymnema Sylvestre, Phyllanthus Emblica, Neopicrorhiza Picrorhiza, Curcuma Longa, Cinnamomum Verum	Hydroxypropyl Methylcellulose, Rice Flour
Gluco 6	Vitamin C: 52.5 mg (58% DV), Vitamin E: 15.75 mg (105% DV), Biotin: 315 mcg (1050% DV), Magnesium: 125 mg (30% DV), Zinc: 7.5 mg (68% DV), Manganese: 1 mg (43% DV), Chromium: 1 mg (43% DV)	Juniper Berry, Alpha Lipoic Acid, Bitter Melon, Cayenne Pepper, Licorice Root, Cinnamon, Banaba Leaf, White Mulberry, Yarrow Flower, Taurine, Gymnema Sylvestre	Not specified
Gluco Fence	Vitamin C: 50 mg (84% DV), Zinc: 7.5 mg (68% DV), Chromium: 2 mg (6% DV)	Turmeric, Cinnamon, Prickly Pear, Cassia, Goji Berry, Bitter Melon, Holy Basil, Olive Leaf	Gelatin Capsule, Rice Flour, Magnesium Stearate, Microcrystalline Cellulose, Silicon Dioxide
Gluco Tru	Vitamin C: 50 mg (84% DV), Vitamin E: 10 mg (67% DV), Biotin: 300 mcg (1000% DV), Magnesium: 125 mg (30% DV), Zinc: 7.5 mg (68% DV), Manganese: 1 mg (43% DV), Chromium: 67 mcg (191% DV)	Cinnamon, Licorice Root, Guggul, Bitter Melon, Gymnema Sylvestre, Alpha Lipoic Acid, L-Taurine, Yarrow Flowers, Banaba Leaf, Juniper Berry, Vanadium	Gelatin, Microcrystalline Cellulose, Silicon Dioxide, Magnesium Stearate, Rice Flour
GlucoBerry	Biotin: 2 mg (3333% DV), Chromium: 600 mcg (857% DV)	Gymnema Sylvestre, Maqui Berry	Hypromellose, Magnesium Stearate, Silicon Dioxide
Gluconite	Vitamin A: 300 mcg RAE (33% DV), Vitamin C: 500 mg (83% DV), Vitamin D: 1000 IU (250% DV), Vitamin K: 60 mcg (75% DV), Zinc: 5 mg (33% DV), Chromium: 10 mcg (29% DV)	Chamomile, Hibiscus, Passionflower, Tryptophan, GABA, Stevia, Hops, Melatonin, White Willow Bark	Not specified
Glucotrust	Vitamin C: 60 mg (100% DV), Vitamin B3: 2.5 mg NE (16% DV), Vitamin B6: 5 mg (294% DV), Folate: 200 mcg DFE (50% DV), Vitamin B12: 100 mcg (1667% DV)	Hawthorne, Garlic, Hibiscus, Coleus Forskolin, Olive, Buchu, Uva Ursi, Juniper, Green Tea	Gelatin, Microcrystalline Cellulose, Silicon Dioxide
Sugar Defender	Not specified	Organic Hawthorn, Organic Horse Chestnut, Organic Grape Seed, Organic Stone Root, Organic Motherwort, Organic Gotu Kola, Organic Butcher’s Broom	Vegetable Glycerin, Purified Water, Organic Lavender, Organic Rose, Trace Minerals Blend

Blood sugar supplements are popular for people who want to manage their blood sugar levels naturally. These supplements often contain a mix of ingredients that help support healthy blood sugar, improve insulin sensitivity, and boost overall health.

Most ingredients come from natural sources like herbs, minerals, and vitamins. Many have been used for years in traditional medicine and are now supported by modern research. This list covers the common ingredients found in blood sugar supplements, explaining what they are and how they work.

Whether you’re looking for ways to support your blood sugar or just curious about what’s inside these supplements, this guide will help you understand the key ingredients and their benefits.

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1. Alpha Lipoic Acid

Pros: Powerful antioxidant that can reduce oxidative stress, improve nerve function, and lower blood sugar levels.

Cons: Can cause nausea, rashes, or dizziness in some people; high doses might interfere with thyroid function.

2. Banaba Leaf Extract

Pros: Contains corosolic acid, which may help lower blood sugar levels and improve insulin sensitivity.

Cons: Limited research; potential side effects include low blood sugar, especially when combined with other glucose-lowering medications.

3. Barberry (Berberis vulgaris) Root Bark Extract

Pros: Contains berberine, which has antimicrobial properties and may help regulate blood sugar and cholesterol levels.

Cons: Can cause gastrointestinal issues like constipation, and long-term use may lead to vitamin B deficiencies.

4. Biotin

Pros: Supports healthy skin, hair, and nails; may help manage blood sugar in type 2 diabetes.

Cons: High doses can interfere with lab tests; most people get enough biotin through their diet, making supplementation unnecessary.

5. Bitter Melon Extract (Momordica charantia)

Pros: May help lower blood sugar levels and has antioxidant properties.

Cons: Can cause stomach discomfort and interact with diabetes medications, leading to hypoglycemia.

6. Buchu (Agathosma betulina) Leaf Extract

Pros: Traditionally used for urinary tract health and as a diuretic; may have anti-inflammatory properties.

Cons: Limited scientific evidence; can cause stomach upset and should be avoided by pregnant women.

7. Butcher’s Broom (Root) Extract

Pros: May improve circulation and reduce symptoms of chronic venous insufficiency.

Cons: Can cause nausea or upset stomach in some people; may interact with blood pressure medications.

8. Cacao (Theobroma cacao) Bean Extract

Pros: Rich in antioxidants and flavonoids, which can improve heart health and reduce inflammation.

Cons: Contains caffeine, which can cause jitteriness or insomnia; may also interact with certain medications.

9. Calcium

Pros: Essential for bone health and muscle function.

Cons: Excessive intake can lead to kidney stones and interfere with the absorption of other minerals.

10. Cassia Extract (Cinnamomum aromaticum) Bark

Pros: Contains cinnamaldehyde, which has anti-inflammatory and antimicrobial properties; may help lower blood sugar.

Cons: High amounts can cause liver damage due to coumarin content; can interact with blood-thinning medications.

11. Cayenne Pepper Powder

Pros: Contains capsaicin, which may boost metabolism, reduce pain, and improve circulation.

Cons: Can cause stomach irritation or heartburn, especially in those with sensitive stomachs.

12. Chamomile Flower Powder

Pros: Known for its calming effects and can improve sleep quality; has anti-inflammatory and antioxidant properties.

Cons: May cause allergic reactions, especially in people allergic to ragweed; can interact with blood-thinning medications.

13. Cinnamon Bark Powder (Cinnamomum cassia)

Pros: May help lower blood sugar levels and has antioxidant and anti-inflammatory properties.

Cons: Contains coumarin, which can be toxic to the liver in high doses; may interact with diabetes medications.

14. Clove (Syzygium aromaticum) Bud Extract

Pros: Has strong antioxidant properties and may help manage blood sugar levels; also has antimicrobial effects. Cons: Can cause allergic reactions or irritation, and excessive consumption can lead to liver toxicity.

15. Coleus Forskolin Extract (Coleus forskohlii)

Pros: May aid in fat loss and improve heart health; also has potential benefits for asthma and high blood pressure.

Cons: Can lower blood pressure, leading to dizziness or fainting; may interact with blood thinners and other medications.

16. Chromium (as Amino Acid Chelate, HVP Chelate, Picolinate)

Pros: May help improve insulin sensitivity and lower blood sugar levels.

Cons: High doses can lead to kidney or liver damage; potential interactions with diabetes medications.

17. Curcuma Longa (Rhizome)

Pros: Contains curcumin, which has strong anti-inflammatory and antioxidant properties; may reduce pain and improve heart health.

Cons: Poorly absorbed by the body; can cause stomach upset or interact with blood-thinning medications.

18. Cuggul (Commiphora mukul) Resin Extract

Pros: Traditionally used in Ayurvedic medicine to treat inflammation and lower cholesterol. Cons: Can cause skin rashes, headaches, and gastrointestinal issues; may interact with thyroid medications.

19. Eleuthero (Eleutherococcus senticosus) Root Extract

Pros: Adaptogen that may reduce stress, improve energy levels, and support immune function.

Cons: Can cause insomnia, anxiety, or irritability in some people; may interact with heart medications.

20. Folate (from Folic Acid)

Pros: Essential for DNA synthesis and cell division; important during pregnancy for preventing neural tube defects. Cons: Excessive intake can mask vitamin B12 deficiency and may lead to other health issues.

21. Gamma-Aminobutyric Acid (GABA)

Pros: Known for its calming effects on the nervous system; may help reduce anxiety and improve sleep.

Cons: Can cause drowsiness, headaches, or digestive issues; not well-absorbed orally, so effectiveness may be limited.

22. Garlic Extract (Allium sativum)

Pros: Has antimicrobial and antioxidant properties; may help lower blood pressure and cholesterol levels.

Cons: Can cause bad breath, heartburn, or stomach upset; may interact with blood-thinning medications.

23. Gelatin

Pros: Supports joint health and skin elasticity; used as a stabilizer in supplements.

Cons: Sourced from animal products, making it unsuitable for vegetarians and vegans.

24. Glutamic Acid

Pros: Important for brain function and a key component in the synthesis of proteins.

Cons: Excessive intake can cause headaches, nausea, and other symptoms, especially in sensitive individuals.

25. Goji Berry Extract (Lycium barbarum)

Pros: Rich in antioxidants, vitamins, and minerals; may improve immune function and eye health.

Cons: Can interact with blood-thinning medications and may cause digestive issues in some people.

26. Grape Seed Extract (Vitis vinifera)

Pros: High in antioxidants; may support cardiovascular health and improve circulation.

Cons: Can cause headaches, dizziness, or nausea; may interact with blood-thinning medications.

27. Green Tea Extract (Camellia sinensis)

Pros: Rich in antioxidants, particularly EGCG; may support weight loss and improve heart health.

Cons: Contains caffeine, which can cause jitteriness or insomnia; may interact with certain medications.

28. Guggul (10% extract)

Pros: May lower cholesterol and support weight loss; traditionally used in Ayurvedic medicine.

Cons: Can cause skin reactions, headaches, or digestive issues; may interact with thyroid and other medications.

29. Gymnema Sylvestre Leaf Powder

Pros: May help reduce sugar absorption in the gut and improve insulin function.

Cons: Can cause hypoglycemia when combined with diabetes medications; limited long-term safety data.

30. Hawthorne Powder (Crataegus laevigata)

Pros: Supports heart health by improving blood flow and reducing blood pressure.

Cons: Can interact with blood pressure and heart medications; may cause dizziness or nausea.

31. Hibiscus Powder (Hibiscus sabdariffa)

Pros: May lower blood pressure and support cardiovascular health; has antioxidant properties.

Cons: Can cause blood pressure to drop too low in some individuals; may interact with certain medications.

32. Holy Basil Extract (Ocimum tenuiflorum)

Pros: Adaptogen that may help reduce stress and support immune function; has anti-inflammatory properties. Cons: Can lower blood sugar, leading to hypoglycemia; may interact with anticoagulants and other medications.

33. Hops Flower Powder

Pros: Has sedative properties, which may help with sleep disorders; also has anti-inflammatory effects.

Cons: Can cause drowsiness during the day; may interact with sedatives and other medications.

34. Horse Chestnut (Fruit/Hull/Seed) Extract

Pros: May improve circulation and reduce symptoms of chronic venous insufficiency.

Cons: Can cause gastrointestinal issues or allergic reactions; raw horse chestnut is toxic if not processed correctly.

35. Hydroxypropyl Methylcellulose (Veggie Capsule)

Pros: Plant-based capsule alternative; used for controlled release of active ingredients.

Cons: Generally safe but can cause mild digestive discomfort in some individuals.

36. Iron

Pros: Essential for oxygen transport in the blood and preventing anemia.

Cons: Excessive iron can cause toxicity, leading to symptoms like nausea, vomiting, and organ damage.

37. Juniper Berry Powder (Juniperus communis)

Pros: Traditionally used for digestive health and as a diuretic; may have anti-inflammatory properties.

Cons: Can cause kidney irritation in large doses; may interact with diuretics and other medications.

38. L-Taurine

Pros: Supports cardiovascular health and may improve exercise performance; also has antioxidant properties. Cons: High doses may cause digestive discomfort or interact with certain medications.

39. Lavender (Flower) Extract

Pros: Known for its calming effects; may reduce anxiety and improve sleep quality.

Cons: Can cause skin irritation or allergic reactions in some individuals; excessive intake may lead to nausea.

40. Licorice Root Extract

Pros: May help with digestive issues and support respiratory health; has anti-inflammatory properties.

Cons: Can raise blood pressure and cause electrolyte imbalances; should be avoided in large amounts.

41. Magnesium (as Magnesium Oxide)

Pros: Essential for muscle function, nerve signaling, and bone health; may help reduce blood pressure.

Cons: High doses can cause diarrhea, nausea, and abdominal cramping; poor absorption compared to other forms of magnesium.

42. Maqui Berry (Aristotelia chilensis) Extract

Pros: High in antioxidants, particularly anthocyanins; may support eye health and reduce inflammation.

Cons: Limited research on long-term effects; can be expensive due to its superfood status.

43. Melatonin

Pros: Regulates sleep-wake cycles; may help with insomnia and improve sleep quality.

Cons: Can cause daytime drowsiness, headaches, or dizziness; long-term use may affect natural melatonin production.

44. Manganese (as Amino Acid Chelate)

Pros: Important for bone health, metabolism, and antioxidant function.

Cons: Excessive intake can lead to neurological problems, particularly in those with liver disease.

45. Microcrystalline Cellulose

Pros: Commonly used as a binder and filler in tablets; generally considered safe.

Cons: In rare cases, can cause gastrointestinal discomfort or allergic reactions.

46. Motherwort (Flower/Leaf/Stem) Extract

Pros: Traditionally used for heart health and to reduce anxiety; may have mild sedative effects.

Cons: Can cause digestive upset or allergic reactions; may interact with heart medications.

47. Mormordica charantia (Fruit)

Pros: May help lower blood sugar levels and has antioxidant properties.

Cons: Can cause stomach discomfort and interact with diabetes medications, leading to hypoglycemia.

48. Neopicrorhiza Picrorhiza Scrophulariiflora Kurroa (Root)

Pros: Used in traditional medicine for liver health and immune support; has anti-inflammatory properties.

Cons: Limited research on safety and efficacy; potential for gastrointestinal side effects.

49. Niacin (Vitamin B3)

Pros: Supports cardiovascular health by improving cholesterol levels; essential for energy production.

Cons: Can cause flushing, itching, and gastrointestinal issues in high doses; may interact with certain medications.

50. Olive Leaf Extract (Olea europaea)

Pros: Rich in antioxidants, particularly oleuropein; may support cardiovascular health and immune function. Cons: Can lower blood pressure, leading to dizziness or lightheadedness; may interact with blood pressure medications.

51. Passionflower Flower Extract

Pros: Known for its calming effects; may help reduce anxiety and improve sleep.

Cons: Can cause drowsiness during the day; may interact with sedatives and other medications.

52. Phyllanthus Emblica Officinalis (Fruit)

Pros: High in vitamin C and antioxidants; may support immune health and reduce inflammation.

Cons: Can cause digestive discomfort in large doses; limited research on long-term effects.

53. Pine (Pinus pinaster) Bark Extract

Pros: Rich in antioxidants, particularly proanthocyanidins; may support cardiovascular health and improve circulation.

Cons: Can cause gastrointestinal issues or allergic reactions in some individuals.

54. Prickly Pear Extract (Opuntia ficus-indica)

Pros: May help lower blood sugar levels and has antioxidant properties; also supports digestive health.

Cons: Can cause digestive discomfort, particularly diarrhea or bloating, in some people.

55. Protein

Pros: Essential for muscle repair and overall body function; supports immune health.

Cons: Excessive intake can strain the kidneys and may lead to digestive issues like bloating or constipation.

56. Retinyl Acetate (Vitamin A)

Pros: Essential for vision, immune function, and skin health.

Cons: Excessive intake can lead to toxicity, causing symptoms like nausea, headache, and liver damage.

57. Rhodiola Rosea (Rhodiola rosea) Root Extract

Pros: Adaptogen that may improve energy levels, reduce stress, and support cognitive function.

Cons: Can cause dizziness, dry mouth, or headaches; may interact with certain medications.

58. Rice Flour

Pros: Used as a filler or binder in supplements; generally considered safe and hypoallergenic.

Cons: Limited nutritional value; can cause bloating or gas in some individuals.

59. Silicon Dioxide

Pros: Used as an anti-caking agent in supplements; generally considered safe.

Cons: Inhalation in large amounts (occupational hazard) can cause lung issues, but this is not a concern in supplement use.

60. Stearic Acid

Pros: Commonly used as a lubricant in supplement manufacturing; generally considered safe.

Cons: High intake may contribute to heart disease, although evidence is not conclusive.

61. Stevia (Rebaudioside A)

Pros: Natural sweetener with no calories; may help regulate blood sugar levels.

Cons: Can have a bitter aftertaste; some people may experience digestive discomfort.

62. Stone Root (Root) Extract

Pros: Traditionally used for digestive and kidney health; may have anti-inflammatory properties.

Cons: Limited research; can cause gastrointestinal issues or allergic reactions.

63. Sugar

Pros: Provides quick energy and improves the taste of supplements.

Cons: Can contribute to weight gain, tooth decay, and blood sugar spikes, especially in large amounts.

64. Swertia Chirayita (Leaf)

Pros: Traditionally used for liver health and as an anti-inflammatory agent; may support digestive health.

Cons: Limited research; potential for gastrointestinal side effects.

65. Taurine

Pros: Supports cardiovascular health and may improve exercise performance; also has antioxidant properties. Cons: High doses may cause digestive discomfort or interact with certain medications.

66. Trace Minerals Blend

Pros: Provides essential minerals that support various bodily functions, including bone health and enzyme activity.

Cons: Over-supplementation can lead to imbalances and potential toxicity.

67. Trigonella Foenum Graecum (Seed)

Pros: Commonly known as fenugreek, may help lower blood sugar and cholesterol levels; also has anti-inflammatory properties.

Cons: Can cause gastrointestinal issues like diarrhea or gas; may interact with blood-thinning medications.

68. Tryptophan

Pros: Amino acid that is a precursor to serotonin; may help improve mood and sleep.

Cons: Can cause drowsiness, nausea, or headaches; excessive intake may lead to serotonin syndrome when combined with other serotonin-boosting substances.

69. Turmeric (Curcuma longa) Rhizome

Pros: Contains curcumin, which has strong anti-inflammatory and antioxidant properties; may reduce pain and improve heart health.

Cons: Poorly absorbed by the body; can cause stomach upset or interact with blood-thinning medications.

70. Uva Ursi Extract (Arctostaphylos uva-ursi)

Pros: Traditionally used for urinary tract health; has antimicrobial properties.

Cons: Can cause stomach upset or liver damage if used in large amounts over long periods.

71. Vanadium (as vanadyl sulfate)

Pros: May help improve insulin sensitivity and support blood sugar regulation.

Cons: Can cause stomach upset, diarrhea, and kidney damage in high doses; long-term safety is unclear.

72. Vitamin B6 (as Pyridoxine HCl)

Pros: Important for brain function, mood regulation, and metabolism.

Cons: High doses can cause nerve damage over time; potential for interactions with certain medications.

73. Vitamin B12 (as Cyanocobalamin)

Pros: Essential for red blood cell formation, DNA synthesis, and nerve function; may improve energy levels. Cons: High doses can cause skin rashes or gastrointestinal issues in some people; rare interactions with certain medications.

74. Vitamin C (Ascorbic Acid)

Pros: Powerful antioxidant that supports immune function and skin health; helps with iron absorption.

Cons: High doses can cause stomach upset, diarrhea, and kidney stones in susceptible individuals.

75. Vitamin D (as Cholecalciferol)

Pros: Essential for bone health, immune function, and mood regulation; helps the body absorb calcium.

Cons: Excessive intake can lead to hypercalcemia, causing nausea, weakness, and kidney problems.

76. Vitamin E (as d-Alpha Tocopheryl Succinate)

Pros: Antioxidant that supports skin health, immune function, and heart health.

Cons: High doses can increase the risk of bleeding, especially when combined with blood-thinning medications.

77. Vitamin K (Primrose)

Pros: Essential for blood clotting and bone health; may support cardiovascular health.

Cons: Can interact with blood-thinning medications, reducing their effectiveness.

78. White Mulberry Leaf Powder

Pros: May help lower blood sugar levels and support cardiovascular health; has antioxidant properties.

Cons: Limited research; potential for mild digestive issues.

79. White Willow Bark Extract

Pros: Contains salicin, a natural precursor to aspirin; may reduce pain and inflammation.

Cons: Can cause stomach irritation, especially in people with ulcers; may interact with blood-thinning medications.

80. Yarrow Flower Powder

Pros: Traditionally used for digestive issues and wound healing; has anti-inflammatory properties.

Cons: Can cause allergic reactions, especially in those allergic to ragweed; potential for digestive upset.

81. Zinc (as Zinc Oxide, Zinc Citrate)

Pros: Supports immune function, wound healing, and DNA synthesis.

Cons: Excessive intake can cause nausea, vomiting, and interfere with the absorption of other essential minerals.